Phentermine mechanism of action?

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Study for the NBME Form 13 Test with our comprehensive quiz collection, featuring flashcards and multiple-choice questions to ensure your readiness. Enhance your knowledge with detailed explanations for each question.

Multiple Choice

Phentermine mechanism of action?

Explanation:
Phentermine works by acting as a CNS stimulant that increases norepinephrine release, producing appetite suppression. This sympathomimetic effect boosts central sympathetic activity, particularly in the hypothalamic pathways that regulate hunger, leading to reduced appetite and modest increases in energy expenditure. It is not a serotonin reuptake inhibitor, a GABA receptor agonist, or an alpha-adrenergic blocker, which is why those mechanisms don’t explain phentermine’s effects.

Phentermine works by acting as a CNS stimulant that increases norepinephrine release, producing appetite suppression. This sympathomimetic effect boosts central sympathetic activity, particularly in the hypothalamic pathways that regulate hunger, leading to reduced appetite and modest increases in energy expenditure. It is not a serotonin reuptake inhibitor, a GABA receptor agonist, or an alpha-adrenergic blocker, which is why those mechanisms don’t explain phentermine’s effects.

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