True; lithium can cause serotonin syndrome.

• A. False
• B. Not known
• C. Only with SSRIs
• D. True

Answer: (D)

Serotonin syndrome results from excessive serotonergic activity in the central nervous system, usually due to drug interactions or overdose with serotonergic agents. Lithium is not a classic serotonergic drug, but it can contribute to serotonin syndrome, especially when used with other serotonergic medications such as SSRIs or SNRIs. There are rare reports of serotonin syndrome arising in patients on lithium, and the risk is higher when compatible drugs are combined. So the statement is true because lithium can play a role in precipitating serotonin syndrome, even though it is not a primary serotonergic agent. If serotonin syndrome is suspected, discontinue offending drugs and provide supportive care; benzodiazepines can help with agitation, and severe cases may require specific anti-serotonergic treatment.