Which thyroid function pattern is typical of primary hypothyroidism?

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Study for the NBME Form 13 Test with our comprehensive quiz collection, featuring flashcards and multiple-choice questions to ensure your readiness. Enhance your knowledge with detailed explanations for each question.

Multiple Choice

Which thyroid function pattern is typical of primary hypothyroidism?

Explanation:
Primary hypothyroidism occurs when the thyroid gland itself can’t produce enough thyroid hormone. Because the body’s feedback system detects low hormone levels, the pituitary increases TSH stimulation in an attempt to boost the thyroid. The result is a high TSH level with a low free T4 level, which is the classic pattern for this condition. This differs from central (pituitary or hypothalamic) hypothyroidism, where TSH is low or inappropriately normal even though T4 is low, and from hyperthyroidism, where TSH is suppressed and T4 is high.

Primary hypothyroidism occurs when the thyroid gland itself can’t produce enough thyroid hormone. Because the body’s feedback system detects low hormone levels, the pituitary increases TSH stimulation in an attempt to boost the thyroid. The result is a high TSH level with a low free T4 level, which is the classic pattern for this condition. This differs from central (pituitary or hypothalamic) hypothyroidism, where TSH is low or inappropriately normal even though T4 is low, and from hyperthyroidism, where TSH is suppressed and T4 is high.

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